Xie MR, Dang JY, Han HJ, Wang WZ, Liu JW, He XH, Zhang YQ. Synthesis and self-assembly of well-defined polymer brushes with high grafting density of hydrophobic poly(epsilon-caprolactone) and hydrophilic poly(2-(dimethylamino)ethyl methacrylate) side chains. Xie MR, Dang JY, Shi JX, Han HJ, Song CM, Huang W, Zhang YQ. Development of pH-responsive core-shell nanocarriers for delivery of therapeutic and diagnostic agents. Xu SJ, Luo Y, Graeser R, Warnecke A, Kratz F, Hauff P, Licha K, Haag R. Macromolecular nanocapsule derived from hyperbranched polyethylenimine (HPEI): Mechanism of guest encapsulation versus molecular parameters. Watersoluble dendritic core-shell-type architectures based on polyglycerol for solubilization of hydrophobic drugs. Turk H, Shukla A, Rodrigues PCA, Rehage H, Haag R. Multiarm star polyglycerolblock-poly(HEMA) as a versatile precursor for the preparation of micellar nanocapsules with different properties. Synthesis of amphiphilic hyperbranched polyglycerol polymers and their application as template for size control of gold nanoparticles. Multi-arm star block copolymers based on epsilon-caprolactone with hyperbranched polyglycerol core. Macromolecules, 2000, 33(2): 315–320īurgath A, Sunder A, Neuner I, Mulhaupt R, Frey H. Functional poly(ethylene oxide) multiarm star polymers: Core-first synthesis using hyperbranched polyglycerol initiators. Knischka R, Lutz PJ, Sunder A, Mulhaupt R, Frey H. Facile synthesis and self-assembly of multiheteroarm hyperbranched polymer brushes. Cylindrical molecular brushes: Synthesis, characterization, and properties. In addition, this kind of miktoarms polymer brush also showed the ability of dye loading via host-guest encapsulation, which promises the potential application of spherical molecular brushes in supramolecular chemistry. The brushes could self-assemble hierarchically into spherical micelles, and network-like fibre structures, and again spherical micelles by addition of n-hexane into the dichloromethane or chloroform solution of brushes. AFM and dynamic laser light scattering (DLS) were employed to investigate the self-assembly properties of amphiphilic molecular brushes with closed proportion of hydrophobic and hydrophilic arms. The spherical molecular brushes showed high molecular weights up to 230 kDa, and thus could be visualized by atomic force microscopy (AFM). The resulting miktoarms hyperbranched polymer brushes (HPG- g-C16/PEG350) were characterized by hydrogen-nuclear magnetic resonance ( 1H NMR), Fourier transform infrared (FT-IR) spectroscopy, gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) measurements. Through adjusting the feeding ratio of hydrophobic and hydrophilic arms, a series of brushes with different arm ratios were readily obtained. The parallel click grafting strategy was demonstrated to be highly efficient (∼100%), very fast (∼ 2 h) and well controllable to the amphilicity of molecular brushes. Spherical molecular brushes with amphiphilic heteroarms were facilely synthesized by grafting the arms of hydrophobic 2-azidoethyle palmitate and hydrophilic monoazide-terminated poly(ethylene glycol) onto the core of alkyne-modified hyperbranched polyglycerol (HPG) with high molecular weight ( M n = 122 kDa) via one-pot parallel click chemistry.
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